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Varsha Balkrishna Mane ¹, Surekha Babar ¹, Karishma Waghmare ¹, Anita S. Kulkarni ¹

Affiliations
1 Government College of Pharmacy, Vidyanagar, Karad (MS), IN

Abstract

A versatile, accurate, precise and economic method for simultaneous determination of Domperidone and Omeprazole in fixed dose combination products was developed. The absorbance values at 284.8 nm and 301.2 nm and 290.9nm (isoabsorptive point) were used for the estimation of Domperidone and Omeprazole, respectively without mutual interference. This method obeyed Beer's law in the concentration range of 18-28 μg /ml for Domperidone and 5-30 μg/ml for Omeprazole. The results of analyses have been validated statistically for linearity, accuracy and precision, LOD and LOQ of the proposed method.

Keywords

Domperidone, Omeprazole, Dimetyl Formamide, Distilled Water, Ultraviolet Spectrophotometry.

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Aaisha N. Sagri ¹, Rukhsana A. Rub ¹, Anita S. Kulkarni ², Indrajeet Gonjari ², Dhananjay S. Saindane ³, Umair I. Shaikh ⁴

Affiliations
1 Allana College of Pharmacy, Pune, Maharashtra, IN
2 Govt. College of Pharmacy, Karad, Maharashtra, IN
3 College of Pharmacy, Dhule, Maharashtra, IN
4 Luqman College of Pharmacy, Gulbarga, Maharashtra, IN

Abstract

The aim of this study was to increase the aqueous solubility of Ezetimibe (EZE) by solid dispersions with polyethylene glycol 6000 (PEG 6000) and polyvinylpyrrolidone K-30 (PVP K30). Amorphous solid dispersions were prepared by freeze drying technique. The interaction of EZE with the hydrophilic polymers was evaluated by differential scanning calorimetry (DSC), powder x-ray diffractometry (PXRD) Fourier transformation-infrared spectroscopy (FTIR), Scanning electron microscopy (SEM). PXRD and DSC analysis confirmed the amorphous state of freeze dried formulations with respect to the plain drug. The influence of type of polymer, the ratio of drug to polymer on the solubility and dissolution rate of the drug were also evaluated. The solubility and dissolution rates of EZE were significantly increased by solid dispersions as well as their physical mixtures. The improvement of solubility using polymers was in the following order: PVP K30>PEG 6000.

Keywords

Ezetimibe, PEG-6000, PVP K-30, Solid Dispersion.

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